Egg Donation Program - Donor Medications

Gonadotropin-Releasing Hormone Agonists (GnRH Agonists)

GnRH Agonists are synthetic drugs that interrupt the secretion of LH and FSH hormones from the pituitary gland, resulting in decreased production of estrogen. By decreasing the estrogen production, Pacific Reproductive Center is able to synchronize the donor's menstrual cycle with that of the recipient's.

Because these drugs lower estrogen levels (as occurs in the menopause), menopausal symptoms are common: hot flashes, decreased sex drive, vaginal dryness, headaches, mood swings, and a small loss of bone calcium. These side effects stop when treatment is ended. Although rare, pregnancy is possible while on GnRH drugs, so a diaphragm or condom should be used.

Human Chorionic Gonadotropin (HCG) Trigger

HCG, also called Pregnyl® or Profasi®, is a hormone which starts the final maturation of the eggs to prepare them for fertilization. This medication is administered by intramuscular injection when the ovarian follicles have reached the appropriate stage of growth and development. The usual dosage is 10,000 international units or IU. Egg retrieval will take place approximately 34 to 36 hours after HCG injection.